The ketamine has worn off and House is back to using his cane. New patient is Ezra Powell, a renowned pioneer in the field of medical research. Increasingly debilitated, Ezra demands a stop to the medical tests and help him end his life.
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House, Cuddy, and Wilson go to a medical conference and meet an old friend, while the team deal with a girl whose appendages have swollen but she refuses to tell them the truth about the events leading up to her illness.