House, Cuddy, and Wilson go to a medical conference and meet an old friend, while the team deal with a girl whose appendages have swollen but she refuses to tell them the truth about the events leading up to her illness.
Doris Egan (one of the writers of the episode Known Unknowns) gives further explanation and detail on the story of how House and Cuddy met (explained on ep 7) and how it fits into what we already knew about them.