Box office: Deadpool 2 dethrones Infinity War with $125 million opening 

This weekend, Ryan Reynolds is the Merc With the Money.

is on track to open with an estimated $125 million in ticket sales from 4,349 theaters in the U.S. and Canada, unseating three-time box office champ

and scoring the second-highest debut ever for an R-rated movie.

will fall short of industry projections, which had it in the $130 million to $150 million range, and the original

, which bowed with $132.4 million in February 2016 (thus setting the R-rated opening record). Overseas, the sequel will add about $176.3 million this weekend, for a worldwide total of about $301.3 million.

Directed by David Leitch, from a script by Reynolds, Rhett Reese, and Paul Wernick,

finds the titular antihero (played by Reynolds) protecting a young mutant from a time-traveling tough guy named Cable (Josh Brolin), while gleefully skewering Hollywood’s obsession with superheroes. The cast also includes Julian Dennison, Morena Baccarin, Zazie Beetz, T.J. Miller, and Brianna Hildebrand, plus a host of celebrity cameos.

The Fox film, which cost about $110 million to make, received generally positive reviews from critics (on par with the first film), and audiences gave it an A CinemaScore, suggesting good word-of-mouth prospects.

drops down to second place this weekend, grossing a still-solid $28.7 million in its fourth frame and bringing its domestic total to $595 million. The film will add about $84.4 million overseas, pushing its worldwide total north of $1.8 billion.

The weekend’s other new wide releases are Paramount’s rom-com

. The former film will take in about $12.5 million, good for the No. 3 spot, while the latter will gross about $6 million, landing in sixth place.

stars Diane Keaton, Jane Fonda, Candice Bergen, and Mary Steenburgen as four friends whose love lives are upended when they decide to read the guilty pleasure

, meanwhile, centers on a police dog (voiced by Chris “Ludacris” Bridges) who goes undercover at a dog show with his human partner (Will Arnett) to stop an animal smuggling ring. Raja Gosnell directed.

Both movies garnered lackluster reviews, though audiences gave them solid A-minus CinemaScores.

, with about $7.7 million, and the Gabrielle Union thriller

According to ComScore, overall box office is up 6.3 percent year-to-date. Check out the May 18-20 figures below.